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Regulation of SNAP-25 trafficking and function by palmitoylation

Greaves, Jennifer and Prescott, Gerald R and Gorleku, Oforiwa A and Chamberlain, Luke H (2010) Regulation of SNAP-25 trafficking and function by palmitoylation. Biochemical Society Transactions, 38 (1). pp. 163-166.

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Abstract

The SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor) protein SNAP-25 (25 kDa synaptosome-associated protein) is essential for regulated exocytosis in neuronal and neuroendocrine cells. Whereas the majority of SNARE proteins contain transmembrane domains, SNAP-25 is instead anchored to membranes by the palmitoylation of a central cysteine-rich region. In this review, we discuss the mechanisms of SNAP-25 palmitoylation and how this modification regulates the intracellular trafficking and exocytotic function of this essential protein.

Item type: Article
ID code: 32484
Keywords: acyltransferases, animals, exocytosis, humans, lipoylation, protein transport, synaptosomal-associated protein 25, Therapeutics. Pharmacology, Biochemistry
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 10 Aug 2011 11:12
    Last modified: 05 Sep 2014 10:09
    URI: http://strathprints.strath.ac.uk/id/eprint/32484

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