Greaves, Jennifer and Prescott, Gerald R and Gorleku, Oforiwa A and Chamberlain, Luke H (2010) Regulation of SNAP-25 trafficking and function by palmitoylation. Biochemical Society Transactions, 38 (1). pp. 163-166.
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
The SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor) protein SNAP-25 (25 kDa synaptosome-associated protein) is essential for regulated exocytosis in neuronal and neuroendocrine cells. Whereas the majority of SNARE proteins contain transmembrane domains, SNAP-25 is instead anchored to membranes by the palmitoylation of a central cysteine-rich region. In this review, we discuss the mechanisms of SNAP-25 palmitoylation and how this modification regulates the intracellular trafficking and exocytotic function of this essential protein.
| Item type: | Article |
|---|---|
| ID code: | 32484 |
| Keywords: | acyltransferases, animals, exocytosis, humans, lipoylation, protein transport, synaptosomal-associated protein 25, Therapeutics. Pharmacology |
| Subjects: | Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 10 Aug 2011 11:12 |
| Last modified: | 04 Oct 2012 13:48 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/32484 |
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