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DHHC palmitoyl transferases : substrate interactions and (patho)physiology

Greaves, Jennifer and Chamberlain, Luke H (2011) DHHC palmitoyl transferases : substrate interactions and (patho)physiology. Trends in Biochemical Sciences, 36 (5). pp. 245-253. ISSN 0968-0004

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Abstract

S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation can affect proteins in many different ways, including regulating membrane attachment, intracellular trafficking, and membrane micro-localisation. Intracellular palmitoylation reactions are mediated by a family of recently identified aspartate-histidine-histidine-cysteine (DHHC) palmitoyl transferases. More than 20 DHHC proteins are encoded by mammalian genomes, and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded. Recent studies have highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology.

Item type: Article
ID code: 32479
Notes: Copyright © 2011 Elsevier Ltd. All rights reserved.
Keywords: S-palmitoylation , cellular proteins, intracellular trafficking , DHHC proteins , Therapeutics. Pharmacology
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 10 Aug 2011 10:06
    Last modified: 18 Feb 2014 10:40
    URI: http://strathprints.strath.ac.uk/id/eprint/32479

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