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Comparison of high-specific-activity ultratrace 123/131I-MIBG and carrier-added 123/131I-MIBG on efficacy, pharmacokinetics, and tissue distribution

Barrett, John A and Joyal, John L and Hillier, Shawn M and Maresca, Kevin P and Femia, Frank J and Kronauge, James F and Boyd, Marie and Mairs, Robert J and Babich, John W (2010) Comparison of high-specific-activity ultratrace 123/131I-MIBG and carrier-added 123/131I-MIBG on efficacy, pharmacokinetics, and tissue distribution. Cancer Biotherapy and Radiopharmaceuticals, 25 (3). pp. 299-308. ISSN 1084-9785

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    Abstract

    Metaiodobenzylguanidine (MIBG) is an enzymatically stable synthetic analog of norepinephrine that when radiolabled with diagnostic ((123)I) or therapeutic ((131)I) isotopes has been shown to concentrate highly in sympathetically innervated tissues such as the heart and neuroendocrine tumors that possesses high levels of norepinephrine transporter (NET). As the transport of MIBG by NET is a saturable event, the specific activity of the preparation may have dramatic effects on both the efficacy and safety of the radiodiagnostic/radiotherapeutic. Using a solid labeling approach (Ultratrace), noncarrier-added radiolabeled MIBG can be efficiently produced. In this study, specific activities of >1200 mCi/micromol for (123)I and >1600 mCi/micromol for (131)I have been achieved. A series of studies were performed to assess the impact of cold carrier MIBG on the tissue distribution of (123/131)I-MIBG in the conscious rat and on cardiovascular parameters in the conscious instrumented dog. The present series of studies demonstrated that the carrier-free Ultratrace MIBG radiolabeled with either (123)I or (131)I exhibited similar tissue distribution to the carrier-added radiolabeled MIBG in all nontarget tissues. In tissues that express NETs, the higher the specific activity of the preparation the greater will be the radiopharmaceutical uptake. This was reflected by greater efficacy in the mouse neuroblastoma SK-N-BE(2c) xenograft model and less appreciable cardiovascular side-effects in dogs when the high-specific-activity radiopharmaceutical was used. The increased uptake and retention of Ultratrace (123/131)I-MIBG may translate into a superior diagnostic and therapeutic potential. Lastly, care must be taken when administering therapeutic doses of the current carrier-added (131)I-MIBG because of its potential to cause adverse cardiovascular side-effects, nausea, and vomiting.

    Item type: Article
    ID code: 32463
    Keywords: 3-Iodobenzylguanidine, animal structures, blood pressure , bone marrow, bradycardia, dogs, electrocardiography, heart, heart rate, iodine radioisotopes, isotope labeling, myocardium, neuroblastoma, radiopharmaceuticals, tissue distribution, xenograft model antitumor Assays, Therapeutics. Pharmacology, Radiology Nuclear Medicine and imaging, Cancer Research, Pharmacology, Oncology
    Subjects: Medicine > Therapeutics. Pharmacology
    Department: Faculty of Science > Pure and Applied Chemistry
    Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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      Depositing user: Pure Administrator
      Date Deposited: 08 Aug 2011 15:28
      Last modified: 28 Mar 2014 11:14
      URI: http://strathprints.strath.ac.uk/id/eprint/32463

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