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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Solid-to-solid biocatalysis: thermodynamic feasibility and energy efficiency

Ulijn, R.V. and Halling, P.J. (2004) Solid-to-solid biocatalysis: thermodynamic feasibility and energy efficiency. Green Chemistry, 6 (9). pp. 488-496. ISSN 1463-9262

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Enzymes can catalyse solid-to-solid condensation reactions in highly concentrated aqueous substrate suspensions. Reaction products precipitate from the reaction mixture and very high conversion yields can be obtained in low volume reactors. Solid-to-solid biocatalysis combines the advantages of using enzymes in aqueous media with the high conversion yields that are typically associated with non-aqueous biocatalysis. In this article, methods are presented for the calculation of the Gibbs free energy changes and heats of reaction of condensation reactions to form amides. The overall enthalpy change of the enzymatic reaction was compared to that of the conventional chemical methods and it was found that the enzymatic reaction produces a third of the heat with better atom efficiency.