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Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child

Wood, D.M. and Thomson, Alison and Lawes, M and Jones, A.L. and Dargan, P. (2005) Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child. Therapeutic Drug Monitoring, 27 (4). pp. 405-408. ISSN 0163-4356

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The maximum tolerated single dose of intravenous iron infusion and iron pharmacokinetics are not known in children and not clear in adults. The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity. A TDM consultant discusses the case in the context of toxicokinetic analysis. Because the maximum tolerated dose and pharmacokinetics of intravenous iron preparations are not known, their use in both adults and children should still be undertaken with caution.