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Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms : out of the shadow?

Pyne, Nigel J and Pyne, Susan (2011) Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms : out of the shadow? Trends in Pharmacological Sciences, 32 (8). pp. 443-450.

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Abstract

Receptor tyrosine kinases (RTKs) and G-protein-coupled receptors (GPCRs) can form platforms in which protein signalling components specific for each receptor are shared (owing to close proximity) to produce an integrated response upon engagement of ligands. RTK-GPCR signalling platforms respond to growth factors and GPCR agonists to increase gain over and above that which is normally produced by separate receptors. They can also function to change the spatial context of signalling in response to growth factor activation. The function of RTK-GPCR signalling platforms can be modulated with conformational-specific inhibitors that stabilise defined GPCR states to abrogate both GPCR agonist- and growth factor-stimulated cell responses. In this paper, we provide an opinion of the biology and unusual pharmacology of RTK-GPCR signalling platforms and make comparisons with a more traditional model of crosstalk between RTKs and GPCRs.

Item type: Article
ID code: 32347
Notes: Copyright © 2011 Elsevier Ltd. All rights reserved.
Keywords: ligands, signalling platforms , receptors, cell responses, Pharmacy and materia medica, Pharmacology (medical)
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 28 Jul 2011 16:35
    Last modified: 11 Jul 2014 05:06
    URI: http://strathprints.strath.ac.uk/id/eprint/32347

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