Pyne, Nigel J and Pyne, Susan (2011) Selectivity and specificity of sphingosine 1-phosphate receptor ligands : "off-targets" or complex pharmacology? Frontiers in Pharmacology, 2 (May). p. 26. ISSN 1663-9812
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
A recent perspective published in Frontiers of Pharmacology by Salomone and Waeber (2011) discussed the selectivity and specificity of sphingosine 1-phosphate (S1P) receptor ligands. This perspective surveyed the use of various S1P receptor ligands and attempted to reconcile a number of inconsistencies in the predicted biological outcomes: these were interpreted as "off-target" effects. Therefore the perspective cautioned against the use of these S1P receptor ligands. Here we highlight the complex pharmacology of S1P receptors, which along with "inside-out" signaling might provide an alternative explanation for "off-target" effects.
| Item type: | Article |
|---|---|
| ID code: | 32346 |
| Keywords: | sphingosine 1-phosphate, S1P, receptor ligands, pharmacology , Therapeutics. Pharmacology |
| Subjects: | Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 28 Jul 2011 16:41 |
| Last modified: | 04 Oct 2012 13:48 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/32346 |
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