Site-specific assembly of DNA-based photonic wires by using programmable polyamides

Su, Wu and Schuster, Markus and Bagshaw, Clive R and Rant, Ulrich and Burley, Glenn (2011) Site-specific assembly of DNA-based photonic wires by using programmable polyamides. Angewandte Chemie, 50 (12). pp. 2712-2715. ISSN 0044-8249 (https://doi.org/10.1002/anie.201006735)

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Abstract

The first example of a programmable DNA photonic wire is reported utilizing fluorophore-tethered pyrrole-imidazole polyamides for site-directed fluorophore assembly along a pre-formed DNA duplex (see scheme; PB=Pacific Blue, Cy3=Cyanine 3; orange rectangles=fluorophore). The importance of such control is revealed by efficient energy transport over distances in excess of 27 nm.