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Brain delivery of peptides and proteins

Dufès, Christine (2011) Brain delivery of peptides and proteins. In: Peptide and protein delivery. Elsevier, pp. 105-122. ISBN 978-0-12-384935-9

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Abstract

Therapeutic proteins and peptides have been identified as showing great promise for the treatment of brain cancers and neurodegenerative diseases. However, their delivery to their intended site of action from the blood is hampered by the presence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. Peptides generally do not cross the BBB because these highly polar compounds are not lipid-soluble, and because most circulating peptides do not have access to specialized, BBB receptor-mediated transport systems. Over the past three decades, research has led to a better understanding of the transport mechanisms at the BBB, and to the development of several strategies for improving the delivery of peptides/proteins to the central nervous system (CNS).

Item type: Book Section
ID code: 31795
Keywords: therapeutic proteins , peptides, brain, brain cancers, blood-brain barrier, Therapeutics. Pharmacology
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Bionanotechnology
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 22 Jun 2011 14:49
    Last modified: 12 Jun 2013 14:33
    URI: http://strathprints.strath.ac.uk/id/eprint/31795

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