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Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding

Dryden, C. and Young, David and Campbell, N. and Mactier, H. (2012) Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding. Archives of Disease in Childhood Fetal and Neonatal Edition, 97. F214-F216.

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It is widely accepted that maternal drug-exposed infants demonstrate excessive early weight loss, but this has not previously been quantified. Among 354 term, substitute methadone-exposed infants, median maximal weight losses were 10.2% and 8.5% for breast- and formula-fed infants, respectively (p=0.003). Weight loss was less in small for gestational age compared to appropriately grown infants (p<0.001). There was no association between maximal weight loss and plasma sodium concentration (p=0.807). Relative to non-drug exposed infants, weight loss was more marked in formula-fed infants, 48% of whom demonstrated weight loss in excess of the 95th centile (compared to 23% of exclusively breastfed infants; p<0.001). Median weight loss nadir was on day 5, excepting those infants exclusively breastfed (day 4). These data suggest that excessive neonatal weight loss among breastfed infants of drug-misusing mothers does not necessarily reflect poorly established lactation and may help to guide management of breast feeding in this population.

Item type: Article
ID code: 31784
Keywords: post-natal weight loss, methadone, breast feeding, mathematical statisics, Public health. Hygiene. Preventive Medicine, Probabilities. Mathematical statistics, Medicine(all)
Subjects: Medicine > Public aspects of medicine > Public health. Hygiene. Preventive Medicine
Science > Mathematics > Probabilities. Mathematical statistics
Department: Faculty of Science > Mathematics and Statistics
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 15 Jun 2011 15:48
    Last modified: 05 Sep 2014 09:39

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