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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by Strathclyde researchers involved in aerospace engineering and from the Advanced Space Concepts Laboratory - but also other internationally significant research from within the Department of Mechanical & Aerospace Engineering. Discover why Strathclyde is powering international aerospace research...

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Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

Milner, J. M. and Patel, A. and Davidson, R. K. and Swingler, T. E. and Desilets, A. and Young, D. A. and Kelso, E. B. and Donell, S. T. and Cawston, T. E. and Clark, I. M. and Ferrell, W. R. and Plevin, R. and Lockhart, J. C. and Leduc, R. and Rowan, A. D. (2010) Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. [Review]

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Abstract

Increasing evidence implicates serine proteinases in pathological tissue turnover. This study assessed the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).