Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis

Ferrell, William R. and Kelso, Elizabeth B. and Lockhart, John C. and Burns, Elizabeth and Plevin, Robin and McInnes, Iain B. (2011) Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis. Rheumatology, 50 (Supple). p. 90. ISSN 1462-0324 (https://doi.org/10.1093/rheumatology/ker157)

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Abstract

Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling. We previously demonstrated a role for PAR-2 in adjuvant (1) and rheumatoid arthritis (2). As increasing evidence points to an inflammatory component in OA (3), in the present study we tested the hypothesis that PAR-2 may play a role in the pathogenesis of OA.

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