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A complete shikimate pathway in Toxoplasma gondii : an ancient eukaryotic innovation

Campbell, S A and Richards, T A and Mui, E J and Samuel, B U and Coggins, J R and McLeod, R and Roberts, C W (2004) A complete shikimate pathway in Toxoplasma gondii : an ancient eukaryotic innovation. International Journal for Parasitology, 34 (1). pp. 5-13. ISSN 0020-7519

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Abstract

The shikimate pathway is essential for survival of the apicomplexan parasites Plasmodium falciparum, Toxoplasma gondii and Cryptosporidium parvum. As it is absent in mammals it is a promising therapeutic target. Herein, we describe the genes encoding the shikimate pathway enzymes in T. gondii. The molecular arrangement and phylogeny of the proteins suggests homology with the eukaryotic fungal enzymes, including a pentafunctional AROM. Current rooting of the eukaryotic evolutionary tree infers that the fungi and apicomplexan lineages diverged deeply, suggesting that the arom is an ancient supergene present in early eukaryotes and subsequently lost or replaced in a number of lineages.

Item type: Article
ID code: 31752
Keywords: apicomplexa, toxoplasma, plasmodium, shikimate, arom, DAHP synthase, apicomplexan parasites, plasmodium-falciparum, synthase, sequence, enzyme, strategies, reveals, domains, protein, origin, Infectious Diseases, Parasitology
Subjects: UNSPECIFIED
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 13 Jul 2011 09:57
    Last modified: 05 Sep 2014 09:37
    URI: http://strathprints.strath.ac.uk/id/eprint/31752

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