Campbell, S A and Richards, T A and Mui, E J and Samuel, B U and Coggins, J R and McLeod, R and Roberts, C W (2004) A complete shikimate pathway in Toxoplasma gondii : an ancient eukaryotic innovation. International Journal for Parasitology, 34 (1). pp. 5-13. ISSN 0020-7519Full text not available in this repository. (Request a copy from the Strathclyde author)
The shikimate pathway is essential for survival of the apicomplexan parasites Plasmodium falciparum, Toxoplasma gondii and Cryptosporidium parvum. As it is absent in mammals it is a promising therapeutic target. Herein, we describe the genes encoding the shikimate pathway enzymes in T. gondii. The molecular arrangement and phylogeny of the proteins suggests homology with the eukaryotic fungal enzymes, including a pentafunctional AROM. Current rooting of the eukaryotic evolutionary tree infers that the fungi and apicomplexan lineages diverged deeply, suggesting that the arom is an ancient supergene present in early eukaryotes and subsequently lost or replaced in a number of lineages.
|Keywords:||apicomplexa, toxoplasma, plasmodium, shikimate, arom, DAHP synthase, apicomplexan parasites, plasmodium-falciparum, synthase, sequence, enzyme, strategies, reveals, domains, protein, origin|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||13 Jul 2011 09:57|
|Last modified:||17 Jul 2013 10:38|
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