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The unusual mitochondrial compartment of Cryptosporidium parvum

Henriquez, F L and Richards, T A and Roberts, F and McLeod, R and Roberts, C W (2005) The unusual mitochondrial compartment of Cryptosporidium parvum. Trends in Parasitology, 21 (2). pp. 68-74. ISSN 1471-4922

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Abstract

Recent studies, including the Cryptosporidium parvum Genome Project, have provided evidence for a mitochondrial-derived compartment in this parasite. This organelle appears to lack a genome, and thus must be entirely dependent on nuclear-encoded proteins. Here, we review the evidence for such an organelle in C. parvum and its probable function. There is no adequate treatment for infection by this parasite and so the elucidation of the role of this organelle and the effective targeting of its functions by antimicrobial agents might provide new treatments for infection by C. parvum.

Item type: Article
ID code: 31734
Keywords: plastid terminal oxidase, alternative oxidase, trichomonas-vaginalis, therapeutic implications, giardia-intestinalis, proton translocation, targeting sequences, protein importq, gene iscs, apicomplexan, Pharmacy and materia medica, Infectious Diseases, Parasitology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Mathematics and Statistics
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    Depositing user: Pure Administrator
    Date Deposited: 01 Jul 2011 16:20
    Last modified: 05 Sep 2014 09:36
    URI: http://strathprints.strath.ac.uk/id/eprint/31734

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