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Parasite regulation by host hormones: an old mechanism of host exploitation?

Escobedo, G and Roberts, C W and Carrero, J C and Morales-Montor, J (2005) Parasite regulation by host hormones: an old mechanism of host exploitation? Trends in Parasitology, 21 (12). pp. 588-593. ISSN 1471-4922

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Abstract

Recent experimental evidence suggests that parasites can not only evade immune responses actively but also exploit the hormonal microenvironment within the host to favor their establishment, growth and reproduction. The benefit for parasites of hormonal exploitation is so great that they have evolved structures similar to the steroid and protein hormone receptors expressed in upper vertebrates that can bind to the hormonal metabolites synthesized by the host. This strategy is exemplified by two parasites that respond to adrenal steroids and sexual steroids, respectively: Schistosoma mansoni and Taenia crassiceps. Understanding how the host endocrine system can, under certain circumstances, favor the establishment of a parasite, and characterizing the parasite hormone receptors that are involved might aid the design of hormonal analogs and drugs that affect the parasite exclusively.

Item type: Article
ID code: 31724
Keywords: taenia crassiceps cysticercosis, pituitary adrenal axis, schistosoma mansoni, onchocerca-volvulus, growth factor, in vitro, plasmodium-falciparum, reproductive system, filarial parasites, Pharmacy and materia medica, Infectious Diseases, Parasitology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 13 Jun 2011 15:11
    Last modified: 05 Sep 2014 09:35
    URI: http://strathprints.strath.ac.uk/id/eprint/31724

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