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Depolarization of skeletal muscle cells in culture by a cardiotoxin-like basic polypeptide from the venom of the Taiwan cobra (naja naja atra)

Harvey, A L and Hayashi, K (1987) Depolarization of skeletal muscle cells in culture by a cardiotoxin-like basic polypeptide from the venom of the Taiwan cobra (naja naja atra). Toxicon, 25 (6). pp. 681-684. ISSN 0041-0101

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Abstract

A cardiotoxin-like basic polypeptide from the venom of Naja naja atra is homologous to cardiotoxins from the same venom, but much less toxic. To determine if it acts like the cardiotoxins its depolarizing ability was measured. It was about 10 times less potent than the cardiotoxins. Five amino acids are conserved in the sequences studied, on the exposed second and third loops of the toxin backbone. They may be part of the toxins' interactive site.

Item type: Article
ID code: 31692
Keywords: aimals, chick embryo, cobra venoms, muscles, neuromuscular depolarizing Agents, peptides, Toxicology
Subjects: UNSPECIFIED
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 13 Jul 2011 09:57
    Last modified: 05 Sep 2014 09:34
    URI: http://strathprints.strath.ac.uk/id/eprint/31692

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