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Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals

Anderson, A J and Harvey, A L (1987) Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals. Neuroscience Letters, 82 (2). pp. 177-180. ISSN 0304-3940

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Abstract

Release of acetylcholine at the neuromuscular junctions of skeletal muscle is not sensitive to organic Ca2+ channel blockers. However, in mouse motor nerve endings, extracellular recording reveals that a verapamil-sensitive Ca2+ current can be induced after block of K+ channels. Recordings of extracellular action potentials from inside the perineural sheaths of nerves innervating mouse triangularis sterni muscles reveal that this verapamil-sensitive current is not blocked by omega-conotoxin, and hence, it does not involve channels similar to the L-channels of neuronal cell bodies.