Anderson, A J and Harvey, A L (1987) Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals. Neuroscience Letters, 82 (2). pp. 177-180. ISSN 0304-3940Full text not available in this repository. (Request a copy from the Strathclyde author)
Release of acetylcholine at the neuromuscular junctions of skeletal muscle is not sensitive to organic Ca2+ channel blockers. However, in mouse motor nerve endings, extracellular recording reveals that a verapamil-sensitive Ca2+ current can be induced after block of K+ channels. Recordings of extracellular action potentials from inside the perineural sheaths of nerves innervating mouse triangularis sterni muscles reveal that this verapamil-sensitive current is not blocked by omega-conotoxin, and hence, it does not involve channels similar to the L-channels of neuronal cell bodies.
|Keywords:||animals, anura, calcium, ion channels, male, mice, inbred BALB C mice, mollusk venoms, nerve block, neuromuscular junction, verapamil, omega-conotoxins, Pharmacy and materia medica, Neuroscience(all)|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||13 Jul 2011 08:57|
|Last modified:||06 Jan 2017 09:45|