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A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity

Aneiros, A and García, I and Martínez, J R and Harvey, A L and Anderson, A J and Marshall, D L and Engström, A and Hellman, U and Karlsson, E (1993) A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity. BBA - Biochimica et Biophysica Acta, 1157 (1). pp. 86-92. ISSN 0006-3002

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Abstract

A peptide toxin affecting potassium channels was isolated from the sea anemone Bunodosoma granulifera. It facilitates acetylcholine release at avian neuromuscular junctions, competes with dendrotoxin I, a probe for voltage-dependent potassium channels, for binding to synaptosomal membranes of rat brain with a Ki of 0.7 nM and suppresses K+ currents in rat dorsal root ganglion neurones in culture. It represents a new structural type of potassium channel toxin with the sequence V1RCDWFKETA10CRHAKSLGNC20RTSQKYRANC30AKTLQCC37 (M(r) 4275, three disulfides).

Item type: Article
ID code: 31668
Keywords: amino acid sequence, animals, cultured cells, chickens, gel chromatography, cnidaria, cnidarian venoms, mass spectrometry, molecular sequence data, neuromuscular junction, potassium channels, rats, amino acid sequence homology, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Engineering > Electronic and Electrical Engineering
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    Depositing user: Pure Administrator
    Date Deposited: 13 Jul 2011 09:56
    Last modified: 12 Mar 2012 11:28
    URI: http://strathprints.strath.ac.uk/id/eprint/31668

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