A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity
Aneiros, A and García, I and Martínez, J R and Harvey, A L and Anderson, A J and Marshall, D L and Engström, A and Hellman, U and Karlsson, E (1993) A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity. BBA - Biochimica et Biophysica Acta, 1157 (1). pp. 86-92. ISSN 0006-3002 (https://doi.org/10.1016/0304-4165(93)90082-J)
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A peptide toxin affecting potassium channels was isolated from the sea anemone Bunodosoma granulifera. It facilitates acetylcholine release at avian neuromuscular junctions, competes with dendrotoxin I, a probe for voltage-dependent potassium channels, for binding to synaptosomal membranes of rat brain with a Ki of 0.7 nM and suppresses K+ currents in rat dorsal root ganglion neurones in culture. It represents a new structural type of potassium channel toxin with the sequence V1RCDWFKETA10CRHAKSLGNC20RTSQKYRANC30AKTLQCC37 (M(r) 4275, three disulfides).
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Item type: Article ID code: 31668 Dates: DateEvent7 May 1993PublishedKeywords: amino acid sequence, animals, cultured cells, chickens, gel chromatography, cnidaria, cnidarian venoms, mass spectrometry, molecular sequence data, neuromuscular junction, potassium channels, rats, amino acid sequence homology, Pharmacy and materia medica Subjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 13 Jul 2011 08:56 Last modified: 13 Jan 2024 12:57 URI: https://strathprints.strath.ac.uk/id/eprint/31668