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Toxins from mamba venoms : small proteins with selectivities for different subtypes of muscarinic acetylcholine receptors

Jerusalinsky, D and Harvey, A L (1994) Toxins from mamba venoms : small proteins with selectivities for different subtypes of muscarinic acetylcholine receptors. Trends in Pharmacological Sciences, 15 (11). pp. 424-430. ISSN 0165-6147

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Abstract

Muscarinic acetylcholine receptors exist as five subtypes that are widely distributed throughout the body. Conventional pharmacological agents are not highly selective for particular subtypes, making investigations on the functional significance of the subtypes difficult. Recent findings indicate that mamba snake venoms contain several small proteins ('muscarinic toxins') that are highly specific for muscarinic receptors, and are discussed in this review by Diana Jerusalinsky and Alan Harvey. Some of these toxins act selectively and irreversibly on individual subtypes of receptor, and some are antagonists, while others activate muscarinic receptors. The toxins should be useful tools in studies of the functions of individual receptor subtypes, and comparisons of their three-dimensional structures should give clues about how selective binding to muscarinic receptor subtypes can be obtained.

Item type: Article
ID code: 31647
Keywords: amino acid sequence, animals, elapid venoms, molecular sequence data, proteins, muscarinic receptors, biological toxins, Pharmacy and materia medica, Toxicology, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 13 Jul 2011 09:56
    Last modified: 05 Sep 2014 09:31
    URI: http://strathprints.strath.ac.uk/id/eprint/31647

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