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Medicines from nature : are natural products still relevant to drug discovery?

Harvey, A L (1999) Medicines from nature : are natural products still relevant to drug discovery? Trends in Pharmacological Sciences, 20 (5). pp. 196-198. ISSN 0165-6147

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Abstract

Historically, most drugs have been derived from natural products, but there has been a shift away from their use with the increasing predominance of molecular approaches to drug discovery. Nevertheless, their structural diversity makes them a valuable source of novel lead compounds against newly discovered therapeutic targets. Technical advances in analytical techniques mean that the use of natural products is easier than before. However, there is a widening gap between natural-product researchers in countries rich in biodiversity and drug discovery scientists immersed in proteomics and high-throughput screening.