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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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Toxins 'R' Us : more pharmacological tools from nature's superstore

Harvey, Alan L (2002) Toxins 'R' Us : more pharmacological tools from nature's superstore. Trends in Pharmacological Sciences, 23 (5). pp. 201-203. ISSN 0165-6147

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Abstract

Conus venoms from marine cone snails continue to provide novel bioactive components. Two new classes of conopeptide specifically block alpha(1)-adrenoceptors (rho-conopeptide) and noradrenaline transporters (chi-conopeptides). Both classes are small peptides with two disulfide bonds. Rho-conopeptide is structurally similar to alpha-conotoxins, which block nicotinic acetylcholine receptors, whereas the chi-conopeptides are unrelated to other conotoxins. Both types of conopeptides are non-competitive blockers. Because these peptides demonstrate greater selectivity than current drugs in clinical use, they could lead to the development of improved therapeutics.