Harvey, Alan L and Cree, Ian A (2010) High-throughput screening of natural products for cancer therapy. Planta Medica, 76 (11). pp. 1080-1086.
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Natural products have been the biggest single source of anticancer drugs and there are continued efforts to explore the chemical diversity provided by nature in order to find new lead compounds. Bioassay test methods have developed into high throughput screening assays using both cell-based and molecular approaches. The various ways to detect effects on cell viability and cell proliferation are summarised and examples are given of developments using three-dimensional cultures and cancer stem cells. Cell-based reporter assays have also been created in order to look more directly for effects on specific physiological pathways. The molecular assays include those directed at microtubules and related proteins and at many different protein kinases.
| Item type: | Article |
|---|---|
| ID code: | 31588 |
| Notes: | Georg Thieme Verlag KG Stuttgart-New York. |
| Keywords: | antineoplastic agents, biological assay, cell culture techniques, cell proliferation, cell survival, genes, high-throughput screening Assays, luciferases, protein kinase inhibitors, substrate specificity, tubulin modulators, tumor cells, cultured, reporter, phytogenic, Biology, Pharmacy and materia medica |
| Subjects: | Science > Natural history > Biology Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 23 Jun 2011 12:43 |
| Last modified: | 12 Mar 2012 11:28 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/31588 |
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