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High-throughput screening of natural products for cancer therapy

Harvey, Alan L and Cree, Ian A (2010) High-throughput screening of natural products for cancer therapy. Planta Medica, 76 (11). pp. 1080-1086.

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Abstract

Natural products have been the biggest single source of anticancer drugs and there are continued efforts to explore the chemical diversity provided by nature in order to find new lead compounds. Bioassay test methods have developed into high throughput screening assays using both cell-based and molecular approaches. The various ways to detect effects on cell viability and cell proliferation are summarised and examples are given of developments using three-dimensional cultures and cancer stem cells. Cell-based reporter assays have also been created in order to look more directly for effects on specific physiological pathways. The molecular assays include those directed at microtubules and related proteins and at many different protein kinases.

Item type: Article
ID code: 31588
Notes: Georg Thieme Verlag KG Stuttgart-New York.
Keywords: antineoplastic agents, biological assay, cell culture techniques, cell proliferation, cell survival, genes, high-throughput screening Assays, luciferases, protein kinase inhibitors, substrate specificity, tubulin modulators, tumor cells, cultured, reporter, phytogenic, Biology, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects: Science > Natural history > Biology
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 23 Jun 2011 12:43
Last modified: 27 Mar 2014 09:25
URI: http://strathprints.strath.ac.uk/id/eprint/31588

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