Spencer, John and Rathnam, Rajendra P. and Harvey, Alan L. and Clements, Carol J. and Clark, Rachel L. and Barrett, Michael P. and Wong, Pui Ee and Male, Louise and Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic and Medicinal Chemistry, 19 (5). pp. 1802-1815.
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1016/j.bmc.2011.01.010
Abstract
A library of 1,4-benzodiazepines has been synthesized and evaluated against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis. Benzodiazepines possessing a P2- transporter motif were found to have MIC values as low as 0.78 μM.
| Item type: | Article |
|---|---|
| ID code: | 31585 |
| Notes: | Copyright © 2011 Elsevier Ltd. All rights reserved. |
| Keywords: | synthesis, biological evaluation , 1,4-benzodiazepin-2-ones , antitrypanosomal activity , parallel synthesis, trypanosoma , benzodiazepines, microwaves, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Pharmaceutical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 15 Jun 2011 14:45 |
| Last modified: | 07 Feb 2013 20:37 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/31585 |
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