Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease

Hoehn, Thomas and Stiller, Brigitte and McPhaden, Allan R. and Wadsworth, Roger M. (2009) Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease. Respiratory Research, 10. ISSN 1465-9921

[img]
Preview
Text (Hoehn-etal-RR-2009-Nitric-oxide-synthases-in-infants-and-children-with-pulmonary-hypertension)
Hoehn_etal_RR_2009_Nitric_oxide_synthases_in_infants_and_children_with_pulmonary_hypertension.pdf - Final Published Version
License: Creative Commons Attribution 2.5 logo

Download (1MB) | Preview

Abstract

Nitric oxide is an important regulator of vascular tone in the pulmonary circulation. Surgical correction of congenital heart disease limits pulmonary hypertension to a brief period. The study has measured expression of endothelial (eNOS), inducible (iNOS), and neuronal nitric oxide synthase (nNOS) in the lungs from biopsies of infants with pulmonary hypertension secondary to cardiac abnormalities (n = 26), compared to a control group who did not have pulmonary or cardiac disease (n = 8). eNOS, iNOS and nNOS were identified by immunohistochemistry and quantified in specific cell types. Significant increases of eNOS and iNOS staining were found in pulmonary vascular endothelial cells of patients with congenital heart disease compared to control infants. These changes were confined to endothelial cells and not present in other cell types. Patients who strongly expressed eNOS also had strong expression of iNOS. Upregulation of eNOS and iNOS occurs at an early stage of pulmonary hypertension, and may be a compensatory mechanism limiting the rise in pulmonary artery pressure.