Hoehn, Thomas and Stiller, Brigitte and McPhaden, Allan R. and Wadsworth, Roger M. (2009) Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease. Respiratory Research, 10. ISSN 1465-9921Full text not available in this repository. (Request a copy from the Strathclyde author)
Nitric oxide is an important regulator of vascular tone in the pulmonary circulation. Surgical correction of congenital heart disease limits pulmonary hypertension to a brief period. The study has measured expression of endothelial (eNOS), inducible (iNOS), and neuronal nitric oxide synthase (nNOS) in the lungs from biopsies of infants with pulmonary hypertension secondary to cardiac abnormalities (n = 26), compared to a control group who did not have pulmonary or cardiac disease (n = 8). eNOS, iNOS and nNOS were identified by immunohistochemistry and quantified in specific cell types. Significant increases of eNOS and iNOS staining were found in pulmonary vascular endothelial cells of patients with congenital heart disease compared to control infants. These changes were confined to endothelial cells and not present in other cell types. Patients who strongly expressed eNOS also had strong expression of iNOS. Upregulation of eNOS and iNOS occurs at an early stage of pulmonary hypertension, and may be a compensatory mechanism limiting the rise in pulmonary artery pressure.
|Keywords:||diaphragmatic-hernia, endothelial-cells, chronic hypoxia, expression, gene, rat, therapy, circulation, decreases, newborns, Pharmacy and materia medica, Pulmonary and Respiratory Medicine|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||14 Jun 2011 13:42|
|Last modified:||27 Apr 2016 16:51|