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Pharmacotherapy to improve outcomes in infrainguinal bypass graft surgery : a review of current treatment strategies

Jackson, Andrew J. and Coats, Paul and Orr, Douglas J. and Teenan, R. Paul and Wadsworth, Roger M. (2010) Pharmacotherapy to improve outcomes in infrainguinal bypass graft surgery : a review of current treatment strategies. Annals of Vascular Surgery, 24 (4). pp. 562-572. ISSN 0890-5096

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Abstract

A total of 12,000 infrainguinal bypass grafts are performed annually in the United Kingdom, with outcomes suboptimal: 20% of above-knee vein grafts require intervention by 3 years. Transatlantic Inter-Society Consensus (TASC) guidelines exist on pharmacological management of peripheral vascular disease patients, however, little is recommended regarding optimum pharmacological management following revascularization to improve graft patency. The current recommendation is that all patients are on an antiplatelet agent following bypass grafting, the only intervention with significant evidence supporting use. This article will review pharmacological strategies aimed at improving the survival of infrainguinal vein grafts and the current evidence base for their use.

Item type: Article
ID code: 31489
Keywords: peripheral arterial-disease, coronary balloon angioplasty, muscle-cell-proliferation, activated protein-kinase, intimal hyperplasia, nitric-oxide, oral anticoagulants, randomized-trial, angiographic restenosis, antiplatelet therapy, Pharmacy and materia medica, Surgery, Cardiology and Cardiovascular Medicine
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 25 Jun 2011 05:09
    Last modified: 05 Sep 2014 09:19
    URI: http://strathprints.strath.ac.uk/id/eprint/31489

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