Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

A 1 : 2 co-crystal of isonicotinamide and propionic acid

Oswald, I D H and Motherwell, W D S and Parsons, S (2004) A 1 : 2 co-crystal of isonicotinamide and propionic acid. Acta Crystallographica Section E: Structure Reports, 60. O2380-O2383. ISSN 1600-5368

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Isonicotinamide has been shown to form many 1: 1 co-crystals with monofunctional carboxylic acids, but with propionic acid it forms a co-crystal containing two acid molecules and one isonicotinamide molecule per formula unit, C6H6N2O.-2C(3)H(6)O(2). The crystal structure consists of 'supermolecules' made up of of one isonicotinamide molecule and two acid molecules, and the asymmetric unit contains two of these supermolecules. One of the acid molecules is hydrogen bonded to the pyridine function, and the other to the amide function of the isonicotinamide. Further N - H ... O hydrogen bonds connect these supermolecules into chains which run along the [ 100] direction. The chains are linked into layers perpendicular to ( 010) by C - H ... O and pi-stacking interactions. The layers are then linked together by further C H ... O interactions.

Item type: Article
ID code: 31362
Keywords: isonicotinamid, carboxylic acids , supermolecules, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 01 Jul 2011 16:38
    Last modified: 17 Jul 2013 10:32
    URI: http://strathprints.strath.ac.uk/id/eprint/31362

    Actions (login required)

    View Item