Oswald, I D H and Motherwell, W D S and Parsons, S (2005) Formation of quinol co-crystals with hydrogen-bond acceptors. Acta Crystallographica Section B: Structural Science, 61 (Part 1). pp. 46-57. ISSN 0108-7681Full text not available in this repository. (Request a copy from the Strathclyde author)
The crystal structures of eight new co-crystals of quinol with pyrazine, piperazine, morpholine, pyridine, piperidine, 4,4'-bipyridine, N-methylmorpholine and N,N'-dimethylpiperazine are reported. Quinol forms 1: 1 co-crystals with pyrazine, piperazine and N, N'-dimethylpiperazine, but 1: 2 co-crystals with morpholine, 4,4'-bipyridine, N-methylmorpholine, pyridine and piperidine. This difference can be rationalized in most cases by the presence of, respectively, two or one strong hydrogen-bond acceptor(s) in the guest molecule. The exception to this generalization is 4,4'-bipyridine, which forms a 1: 2 co-crystal, possibly to optimize crystal packing. All structures are dominated by hydrogen bonding between quinol and the guest molecules. A doubly bridging motif, which connects pairs of quinol and guest molecules via NH...O or CH...O interactions, is present in all but the sterically hindered N, N'-dimethylpiperazine and N-methylmorpholine co-crystals.
|Keywords:||cambridge structural database, hydroquinone, symmetry, hydrogen bonding., Pharmacy and materia medica, Biochemistry, Genetics and Molecular Biology(all)|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||01 Jul 2011 14:38|
|Last modified:||22 Mar 2017 11:25|