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Surface-mediated two-dimensional growth of the pharmaceutical carbamazepine

Iski, Erin V. and Johnston, Blair F. and Florence, Alastair J. and Urquhart, Andrew J. and Sykes, E. Charles H. (2010) Surface-mediated two-dimensional growth of the pharmaceutical carbamazepine. ACS Nano, 4 (9). pp. 5061-5068. ISSN 1936-0851

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Abstract

Scanning tunneling microscopy (STM) has become a staple surface microscopy technique for a number of research fields ranging from semiconductor research to heterogeneous catalysis. Pharmaceutical compounds, however, remain largely unstudied. Here we report the first STM study of carbamazepine (CBZ), an anti-epileptic drug, on Au(111) and Cu(111) surfaces. The analysis reveals that CBZ adopts unusual chiral molecular architectures on both metals. These previously unreported structures, which are strikingly different from CBZ packing arrangements observed in 3D crystal structures, indicate that the main molecular architecture is driven by a combination of CBZ intermolecular hydrogen bonding and metal-CBZ interactions. Comparison of the 2D molecular structures reveals large differences in local geometry and packing density that are dependent on the nature of the metal surface. These results have implications for the potential role of metal surfaces as heteronuclei or templating agents for controlling polymorph formation, which continues to be a problem for many compounds in the pharmaceutical industry including CBZ.