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High throughput surface characterization : a review of a new tool for screening prospective biomedical material arrays

Davies, Martyn C. and Alexander, Morgan R. and Hook, Andrew L. and Yang, Jing and Mei, Ying and Taylor, Michael and Urquhart, Andrew J. and Langer, Robert and Anderson, Daniel G. (2010) High throughput surface characterization : a review of a new tool for screening prospective biomedical material arrays. Journal of Drug Targeting, 18 (10). pp. 741-751. ISSN 1061-186X

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Abstract

The application of high throughput surface characterization (HTSC) to the analysis of polymeric biomaterial libraries is an important advancement for the discovery and development of new biomedical materials and is the focus of this review. The potential for HTSC to identify structure/activity relationships for large libraries of materials can be utilized to accelerate materials discovery as well as providing insight into the underlying biological-material interactions. Furthermore, the correlations identified between surface chemical structure and cellular behavior could not have been predicted by a rational design approach based simply on review of bulk structure, which demonstrates the importance of HTSC in the assessment of cell-material and cell-biomolecular interactions that are dependent on surface properties.