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Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

Potta, Sriharsha Gupta and Minemi, Sriharsha and Nukala, Ravi Kumar and Peinado, Chairmane and Lamprou, Dimitrios A. and Urquhart, Andrew and Douroumis, D. (2011) Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. Journal of Microencapsulation, 28 (1). pp. 74-81. ISSN 0265-2048

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Abstract

Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.</.

Item type: Article
ID code: 31343
Keywords: Ibuprofen, solid lipid nanoparticles, high-pressure homogenization, cytotoxicity, controlled drug delivery, release, system, SLN, TIC - Bionanotechnology, Pharmacy and materia medica, Organic Chemistry, Bioengineering, Colloid and Surface Chemistry, Pharmaceutical Science, Physical and Theoretical Chemistry
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
Technology and Innovation Centre > Bionanotechnology
Related URLs:
Depositing user: Pure Administrator
Date Deposited: 23 May 2011 15:03
Last modified: 27 Mar 2014 09:22
URI: http://strathprints.strath.ac.uk/id/eprint/31343

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