Potta, Sriharsha Gupta and Minemi, Sriharsha and Nukala, Ravi Kumar and Peinado, Chairmane and Lamprou, Dimitrios A. and Urquhart, Andrew and Douroumis, D. (2011) Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. Journal of Microencapsulation, 28 (1). pp. 74-81. ISSN 0265-2048Full text not available in this repository. (Request a copy from the Strathclyde author)
Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.</.
|Keywords:||Ibuprofen, solid lipid nanoparticles, high-pressure homogenization, cytotoxicity, controlled drug delivery, release, system, SLN, TIC - Bionanotechnology, Pharmacy and materia medica|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
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|Depositing user:||Pure Administrator|
|Date Deposited:||23 May 2011 15:03|
|Last modified:||14 Jun 2013 08:21|
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