McInnes, I.B. and Gracie, J.A. and Leung, B.P. and Harnett, M. and Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. In: 23rd European Workshop for Rheumatology Research, 2003-03-27, Marseille, France.
|Microsoft Word (strathprints003133.doc) |
Meeting abstract on a novel therapeutic approach to cytokine modulation in articular inflammation. Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.
|Item type:||Conference or Workshop Item (Other)|
|Notes:||Also published in: Arthritis Research & Therapy (2003), 5 (Suppl.1), p52. (This is a variant record)|
|Keywords:||cytokine modulation, physiology, immunology, articular inflammation, Pharmacy and materia medica, Immunology|
|Subjects:||Medicine > Pharmacy and materia medica|
Science > Microbiology > Immunology
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
Faculty of Science > Centre for Biophotonics
|Depositing user:||Strathprints Administrator|
|Date Deposited:||17 Apr 2007|
|Last modified:||04 Oct 2012 17:01|
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