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Open Access research that challenges the mind...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Tryptase as a PAR-2 activator in joint inflammation

Kelso, E.B. and Dunning, L. and Lockhart, J.C. and Ferrell, W.R. and Plevin, R. and Sommerhoff, C.P. (2005) Tryptase as a PAR-2 activator in joint inflammation. In: 25th European Workshop for Rheumatology Research, 2005-02-24 - 2005-02-27.

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Abstract

Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.