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Tryptase as a PAR-2 activator in joint inflammation

Kelso, E.B. and Dunning, L. and Lockhart, J.C. and Ferrell, W.R. and Plevin, R. and Sommerhoff, C.P. (2005) Tryptase as a PAR-2 activator in joint inflammation. In: 25th European Workshop for Rheumatology Research, 2005-02-24 - 2005-02-27.

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Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.