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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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Tryptase as a PAR-2 activator in joint inflammation

Kelso, E.B. and Dunning, L. and Lockhart, J.C. and Ferrell, W.R. and Plevin, R. and Sommerhoff, C.P. (2005) Tryptase as a PAR-2 activator in joint inflammation. In: 25th European Workshop for Rheumatology Research, 2005-02-24 - 2005-02-27.

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Abstract

Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.