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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Tryptase as a PAR-2 activator in joint inflammation

Kelso, E.B. and Dunning, L. and Lockhart, J.C. and Ferrell, W.R. and Plevin, R. and Sommerhoff, C.P. (2005) Tryptase as a PAR-2 activator in joint inflammation. In: 25th European Workshop for Rheumatology Research, 2005-02-24 - 2005-02-27.

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Abstract

Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.