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Prejunctional actions of muscle relaxants : synaptic vesicles and transmitter mobilization as sites of action

Prior, C and Tian, L and Dempster, J and Marshall, I G (1995) Prejunctional actions of muscle relaxants : synaptic vesicles and transmitter mobilization as sites of action. General pharmacology, 26 (4). pp. 659-666. ISSN 0306-3623

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Abstract

Nicotinic antagonists such as tubocurarine affect acetylcholine release from motor nerve terminals at the neuromuscular junction. Electrophysiological studies comparing the prejunctional actions of tubocurarine to those of vesamicol and vecuronium have been used to provide an insight into the mechanisms involved in the prejunctional effects of tubocurarine-like compounds. The observed prejunctional actions of tubocurarine can be accounted for by a model in which the compound has two separately identifiable effects on the nerve terminal. At low frequencies of nerve stimulation tubocurarine augments acetylcholine release while at high frequencies of nerve stimulation tubocurarine depresses acetylcholine release. Both of the effects of tubocurarine on acetylcholine release are a consequence of a change in the number of quanta within the nerve terminal immediately available for release upon nerve stimulation. On the basis of our experimental observations, we suggest that the two prejunctional effects of tubocurarine are mediated through two pharmacologically distinct prejunctional nAChRs.

Item type: Article
ID code: 30909
Keywords: animals, humans, central muscle relaxants, neuromuscular junction, neurotransmitter agents, presynaptic receptors, synaptic vesicles, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 13 Jul 2011 09:55
    Last modified: 12 Mar 2012 11:26
    URI: http://strathprints.strath.ac.uk/id/eprint/30909

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