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Curvedness study on atherosclerosis plaques and its implications to plaque stress

Gao, Hao and Long, Quan and Graves, Martin and Li, Zhiyong and Gillard, Jonathan (2010) Curvedness study on atherosclerosis plaques and its implications to plaque stress. In: IFMBE Proceedings. IFMBE Proceedings Series, 31 (6). Springer, pp. 1507-1510.

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Abstract

Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

Item type: Book Section
ID code: 29431
Keywords: atherosclerosis plaque, stress analysis , curvedness, Electrical engineering. Electronics Nuclear engineering
Subjects: Technology > Electrical engineering. Electronics Nuclear engineering
Department: Faculty of Engineering > Electronic and Electrical Engineering
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 10 Mar 2011 14:39
    Last modified: 06 Sep 2014 06:29
    URI: http://strathprints.strath.ac.uk/id/eprint/29431

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