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Microscopic trends in methanol/water and acetonitrile/water systems

Alzweiri, Muhammed and Parkinson, John and Watson, David and Steer, Steven (2011) Microscopic trends in methanol/water and acetonitrile/water systems. Jordan Journal of Pharmaceutical Sciences, 4 (1). pp. 20-28.

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Abstract

Examination of some trends and differences between acetonitrile/water and methanol/water mixtures has been carried out. These systems are of interest for chromatographers since they are common mobile constituents. Some differences in the molecular arrangement of these solvents were observed from NMR and IR results. These observations might be of use in understanding and developing chromatographic separations. IR studies revealed C-H bond compression in methanol compared with acetonitrile which indicates different molecular arrangement in their aqueous mixtures. NMR and IR results show a clear non-linear behaviour in molecular arrangement. This justifies the deviation of methanol and acetonitrile aqueous solution from the norm. However, both solvents showed similar ionization suppression effects on examples of weak acids and bases.

Item type: Article
ID code: 29296
Keywords: chemical shift, infra-red, nuclear magnetic resonance, physical properties, Methanol, Acetonitrile, Formic Acid, Triethylamine, Pharmacy and materia medica, Pharmaceutical Science
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 07 Mar 2011 23:29
Last modified: 05 Sep 2014 07:50
URI: http://strathprints.strath.ac.uk/id/eprint/29296

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