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Abnormalities of smooth eye and head movement control in Parkinson's disease

Waterston, J A and Barnes, G R and Grealy, M A and Collins, S (1996) Abnormalities of smooth eye and head movement control in Parkinson's disease. Annals of Neurology, 39 (6). pp. 749-60. ISSN 0364-5134

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Abstract

The control of horizontal head and eye movements was examined in 13 nondemented patients with Parkinson's disease (PD) of mild to moderate severity. During pursuit of single-frequency sine waves, smooth component eye velocity was lower in the PD group at frequencies of 1.2 Hz and above; but the differences in overall eye displacement were even greater, indicating an impaired ability to generate catch-up saccades at high frequencies. A corresponding deficit in saccadic performance was observed during a high-frequency saccadic tracking task where predictive saccades of reduced gain and variable timing were generated. During pursuit of pseudo-random target motion with varying degrees of predictability, small differences in smooth component eye velocity were observed, but prediction was otherwise well preserved in the patient group. Vestibulo-ocular reflex (VOR) suppression was also normal during head-free pursuit. No major improvement in smooth pursuit gain could be attributed to drug treatment, based on a comparison of patient results before and after administration of levodopa.

Item type: Article
ID code: 29126
Keywords: Adult, Aged, Female, Head, Humans, Levodopa, Male, Middle Aged, Movement, Parkinson Disease, Pursuit, Smooth, Reaction Time, Reflex, Vestibulo-Ocular, Saccades, Neuroscience. Biological psychiatry. Neuropsychiatry, Medicine
Subjects: Medicine > Internal medicine > Neuroscience. Biological psychiatry. Neuropsychiatry
Medicine
Department: Faculty of Humanities and Social Sciences (HaSS) > School of Psychological Science and Health > Psychology
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 01 Apr 2011 19:40
    Last modified: 04 Oct 2012 13:33
    URI: http://strathprints.strath.ac.uk/id/eprint/29126

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