Waterston, J A and Barnes, G R and Grealy, M A and Collins, S (1996) Abnormalities of smooth eye and head movement control in Parkinson's disease. Annals of Neurology, 39 (6). pp. 749-60. ISSN 0364-5134Full text not available in this repository. (Request a copy from the Strathclyde author)
The control of horizontal head and eye movements was examined in 13 nondemented patients with Parkinson's disease (PD) of mild to moderate severity. During pursuit of single-frequency sine waves, smooth component eye velocity was lower in the PD group at frequencies of 1.2 Hz and above; but the differences in overall eye displacement were even greater, indicating an impaired ability to generate catch-up saccades at high frequencies. A corresponding deficit in saccadic performance was observed during a high-frequency saccadic tracking task where predictive saccades of reduced gain and variable timing were generated. During pursuit of pseudo-random target motion with varying degrees of predictability, small differences in smooth component eye velocity were observed, but prediction was otherwise well preserved in the patient group. Vestibulo-ocular reflex (VOR) suppression was also normal during head-free pursuit. No major improvement in smooth pursuit gain could be attributed to drug treatment, based on a comparison of patient results before and after administration of levodopa.
|Keywords:||Adult, Aged, Female, Head, Humans, Levodopa, Male, Middle Aged, Movement, Parkinson Disease, Pursuit, Smooth, Reaction Time, Reflex, Vestibulo-Ocular, Saccades, Neuroscience. Biological psychiatry. Neuropsychiatry, Medicine, Clinical Neurology, Neurology|
|Subjects:||Medicine > Internal medicine > Neuroscience. Biological psychiatry. Neuropsychiatry
|Department:||Faculty of Humanities and Social Sciences (HaSS) > School of Psychological Science and Health > Psychology|
|Depositing user:||Pure Administrator|
|Date Deposited:||01 Apr 2011 18:40|
|Last modified:||04 May 2016 17:48|