Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

Antibiotic resistance in invasive Streptococcus pneumoniae isolates identified in Scotland between 1999 and 2007

Cooke, Benjamin and Smith, Andrew and Diggle, Mathew and Lamb, Karen Elaine and Robertson, Christopher and Inverarity, Donald and Jefferies, Johanna and Edwards, Giles and Mitchell, Timothy and Clarke, Stuart and McMenamin, Jim (2010) Antibiotic resistance in invasive Streptococcus pneumoniae isolates identified in Scotland between 1999 and 2007. Journal of medical microbiology, 59. pp. 1212-1218. ISSN 0022-2615

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Data from 4,727 invasive isolates of Streptococcus pneumoniae, submitted to the Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory between 1999 and 2007, were analysed to establish susceptibility profiles to penicillin, erythromycin and cefotaxime. Pneumococcal resistance to penicillin over the study period remained low, with only 0.2%, (n= 7/4,727), isolates falling into this category, (MIC great than or equal to 2 mg/l). These isolates have been sporadic, and have mainly represented serogroup 14 (ST9) and 9 (ST156). In comparison, the 'intermediate sensitivity' group, (MIC 0.12-1 mg l-1), ranged between 2-6% per year, the majority from serogroup 9 (ST156). Over the study period we found 12%, (n= 585/4,727), of isolates were erythromycin resistant, (MIC >0.5 mg l1), with the majority, (n= 467; 80%), of these isolates identified as serogroup 14 (ST9). Cephalosporin resistance, (cefotaxime MIC >1mg l-1), was found in only 0.06%, (n= 2/3,135), of isolates. Internationally recognised clones, (Pneumococcal Molecular Epidemiology Network, PMEN), accounted for 35%, (n=28/81), of the penicillin-non-susceptible isolates, and 75%, (n=248/330), of the macrolide-resistant isolates, with ST9 and ST 306 predominating. Between 1999 and 2007 we found that 11.6%, (n=18/155), of the penicillin non-susceptible isolates and 4.8%, (n=28/585), of the macrolide-resistant isolates were from serogroups not covered by the 7-valent conjugate pneumococcal vaccine in use in the UK since 2006. Susceptibility to first line antimicrobial agents for invasive pneumococcal disease, (IPD), in Scotland has remained high over the period 1999-2007.