Neilson, Matthew Paterson and Mackenzie, John and Webb, Steven and Insall, Robert H.
(2010)
*Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell.*
Integrative Biology, 2 (11-12).
pp. 687-695.

## Abstract

In this paper we present a computational tool that enables the simulation of mathematical models of cell migration and chemotaxis on an evolving cell membrane. Recent models require the numerical solution of systems of reaction-diffusion equations on the evolving cell membrane and then the solution state is used to drive the evolution of the cell edge. Previous work involved moving the cell edge using a level set method (LSM). However, the LSM is computationally very expensive, which severely limits the practical usefulness of the algorithm. To address this issue, we have employed the parameterised finite element method (PFEM) as an alternative method for evolving a cell boundary. We show that the PFEM is far more efficient and robust than the LSM. We therefore suggest that the PFEM potentially has an essential role to play in computational modelling efforts towards the understanding of many of the complex issues related to chemotaxis.

Item type: | Article |
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ID code: | 29099 |

Keywords: | finite element method, statistics, biology, Probabilities. Mathematical statistics, Statistics and Probability |

Subjects: | Science > Mathematics > Probabilities. Mathematical statistics |

Department: | Faculty of Science > Mathematics and Statistics > Mathematics Faculty of Science > Mathematics and Statistics |

Depositing user: | Pure Administrator |

Date Deposited: | 22 Mar 2011 12:19 |

Last modified: | 07 Aug 2015 04:04 |

Related URLs: | |

URI: | http://strathprints.strath.ac.uk/id/eprint/29099 |

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