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Formation of artificial lipid bilayers using droplet dielectrophoresis

Aghdaei, Sara and Sandison, Mairi and Zagnoni, Michele and Green, Nicolas G. and Morgan, Hywel (2008) Formation of artificial lipid bilayers using droplet dielectrophoresis. Lab on a Chip, 8 (10). 1617–1620. ISSN 1473-0197

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We describe the formation of artificial bilayer lipid membranes (BLMs) by the controlled, electrical manipulation of aqueous droplets immersed in a lipid–alkane solution. Droplet movement was generated using dielectrophoresis on planar microelectrodes covered in a thin insulator. Droplets, surrounded by lipid monolayers, were brought into contact and spontaneously formed a BLM. The method produced BLMs suitable for single-channel recording of membrane protein activity and the technique can be extended to create programmable BLM arrays and networks.

Item type: Article
ID code: 29052
Keywords: droplet movement , artificial lipid bilayers, lipid bilayers , droplets, Bioengineering, Biomedical Engineering, Biochemistry, Bioengineering, Chemistry(all)
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Department: Faculty of Engineering > Electronic and Electrical Engineering
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Engineering > Biomedical Engineering
Depositing user: Pure Administrator
Date Deposited: 28 Mar 2011 09:20
Last modified: 01 Oct 2015 13:05

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