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An extracellular microelectrode array for monitoring electrogenic cells in culture

Connolly, P. and Clarke, P. and Curtis, A.S.G. and Dow, J.A.T. and Wilkinson, C.D.W. (1990) An extracellular microelectrode array for monitoring electrogenic cells in culture. Biosensors and Bioelectronics, 5 (3). pp. 223-234. ISSN 0956-5663

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Abstract

This paper describes a planar array of microelectrodes developed for monitoring the electrical activity of cells in culture. The device allows the incorporation of surface topographical features in an insulating layer above the electrodes. Semiconductor technology is employed for the fabrication of the gold electrodes and for the deposition and patterning of an insulating layer of silicon nitride. The electrodes have been tested using a cardiac cell culture of chick embryo myocytes, and the physical beating of the cultured cells correlated with the simultaneous extracellular voltage measurements obtained. It was found that extracellular stimulation of the cells was possible via the same electrodes used for recording.

Item type: Article
ID code: 28850
Keywords: extracellular recording, microelectrodes, cell guidance, cardiac cells, Bioengineering, Engineering (General). Civil engineering (General), Biomedical Engineering, Electrochemistry, Biotechnology, Biophysics
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Technology > Engineering (General). Civil engineering (General)
Department: Faculty of Engineering > Bioengineering
Faculty of Education > Sport, Culture and The Arts
Related URLs:
    Depositing user: Ms Ashley Urie
    Date Deposited: 29 Oct 2010 11:55
    Last modified: 05 Sep 2014 04:24
    URI: http://strathprints.strath.ac.uk/id/eprint/28850

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