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Thioctic acid modification of oligonucleotides using an H-phosphonate

Dougan, Jennifer A. and Reid, Andrew K. and Graham, Duncan (2010) Thioctic acid modification of oligonucleotides using an H-phosphonate. Tetrahedron Letters, 51 (44). pp. 5787-5790. ISSN 0040-4039

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    Abstract

    The H-phosphonate of a derivative of thioctic acid (TA) was synthesized and used to introduce a disulfide moiety at the 5'-end of oligonucleotides. This method overcomes the difficulties experienced with the phosphoramidite approach when employing a cyclic disulfide in the starting alcohol. The disulfide-modified oligonucleotides are subsequently used in metallic nanoparticle (Au and Ag) and surface functionalisation for sensitive, sequence specific analytical detection strategies.

    Item type: Article
    ID code: 28671
    Keywords: H-phosphonate, thioctic acid, oligonucleotides, phosphoramidite approach, alcohol, Science (General), Chemistry, Biochemistry, Organic Chemistry, Drug Discovery
    Subjects: Science > Science (General)
    Science > Chemistry
    Department: Faculty of Science > Pure and Applied Chemistry
    Related URLs:
    Depositing user: Mrs Gillian Neeson
    Date Deposited: 15 Nov 2010 10:08
    Last modified: 27 Mar 2014 09:10
    URI: http://strathprints.strath.ac.uk/id/eprint/28671

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