Dougan, Jennifer A. and Reid, Andrew K. and Graham, Duncan (2010) Thioctic acid modification of oligonucleotides using an H-phosphonate. Tetrahedron Letters, 51 (44). pp. 5787-5790. ISSN 0040-4039
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2010.08.107
Abstract
The H-phosphonate of a derivative of thioctic acid (TA) was synthesized and used to introduce a disulfide moiety at the 5'-end of oligonucleotides. This method overcomes the difficulties experienced with the phosphoramidite approach when employing a cyclic disulfide in the starting alcohol. The disulfide-modified oligonucleotides are subsequently used in metallic nanoparticle (Au and Ag) and surface functionalisation for sensitive, sequence specific analytical detection strategies.
| Item type: | Article |
|---|---|
| ID code: | 28671 |
| Keywords: | H-phosphonate, thioctic acid, oligonucleotides, phosphoramidite approach, alcohol, Science (General), Chemistry |
| Subjects: | Science > Science (General) Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry |
| Related URLs: | |
| Depositing user: | Mrs Gillian Neeson |
| Date Deposited: | 15 Nov 2010 10:08 |
| Last modified: | 12 Mar 2012 11:22 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/28671 |
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