Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

The neuropsychological effects of chronicmethylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder

Coghill, David, R and Rhodes, Sinéad M. and Matthews, Keith (2007) The neuropsychological effects of chronicmethylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder. Biological Psychiatry, 62. pp. 954-962. ISSN 0006-3223

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

The reported neuropsychological effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD) are in consistent. The assumed relationships between these neuropsychological effects and clinical efficacy have not been substantiated. Wetherefore investigated the effects of chronic MPH administration on neuropsychological functioning. We conducted a 12-week, placebo-controlled, double-blinded, randomized, crossover trial (MPH .3 and .6 mg/kg/dose andplacebo). Participants were 75 boys aged 7-15 years with ADHD. Neuropsychological performance was assessed with tests taken from theCambridge Neuropsychological Test Automated Battery (CANTAB) battery and a GoNoGo task. ChronicMPHimproved performance (p.001) on aspects of theGoNoGotask (p.02) and on threeCANTABtasks which togethercontributed to a 'recognition memory' component identified through principal components analysis (delayed matching to sample [DMtS],pattern and spatial recognition). There were no effects on other, high or low 'executive demand' tasks (p .05). GoNoGo performanceimprovements were the only neuropsychopharmacological changes associated with clinical response. Poor performance on the DMtS taskwas the sole baseline neuropsychological predictor of clinical response. Chronic MPH predominantly enhanced neuropsychological functioning on 'recognition memory' component tasks withmodest 'executive' demands. Neuropsychological measures offer only modest contributions to the prediction of clinical responses to MPHin ADHD.