Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Cytokines in the systemic inflammatory response syndrome : a review

Jaffer, U. and Wade, R.G. and Gourlay, T. (2010) Cytokines in the systemic inflammatory response syndrome : a review. HSR Proceedings in Intensive Care and Cardiovascular Anesthesia, 2 (3). pp. 161-175.

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Introduction: Patients subject to major surgery, suffering sepsis, major trauma, or following cardiopulmonary bypass exhibit a systemic inflammatory response. This inflammatory response involves a complex array of inflammatory polypeptide molecules known as cytokines. It is well accepted that the loss of local control of the release of these cytokines leads to systemic inflammation and potentially deleterious consequences including the Systemic Inflammatory Response Syndrome (SIRS), Multi-Organ Dysfunction Syndrome (MODS), shock and death. Methods: The Medline database was searched for literature on mechanisms involved in the development of SIRS and potential targets for modifying the inflammatory response. We focus on the novel therapy of cytokine adsorption as a promising removal technology. Results: Accumulating data from human studies and experimental animal models suggests that both pro- and anti- inflammatory cytokines are released following a variety of initiating stimuli including endotoxin release, complement activation, ischaemia reperfusion injury and others. Discussion: Pro-and anti-inflammatory cytokines interact in a complex and unpredictable manner to influence the immune system and eventually cause multiple end organ effects. Cytokine adsorption therapy provides a potential solution to improving outcomes following SIRS.

Item type: Article
ID code: 28580
Keywords: cytokine, systemic, inflammatory response, syndrome, SIRS, Bioengineering, Engineering (General). Civil engineering (General)
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Technology > Engineering (General). Civil engineering (General)
Department: Faculty of Engineering > Bioengineering
Related URLs:
Depositing user: Ms Ashley Urie
Date Deposited: 28 Oct 2010 11:22
Last modified: 19 Jun 2012 14:32
URI: http://strathprints.strath.ac.uk/id/eprint/28580

Actions (login required)

View Item