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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Cellular trans-differentiation and morphogenesis towards the lymphatic lineage in regenerative medicine

Laco, F. and Grant, M.H. and Flint, D.J. and Black, R.A. (2011) Cellular trans-differentiation and morphogenesis towards the lymphatic lineage in regenerative medicine. Stem Cells and Development, 20 (2). pp. 181-195. ISSN 1547-3287

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Abstract

Lymphoedema is a medically irresolvable condition. The lack of therapies addressing lymphatic vessel dysfunction suggests that improved understanding of lymphatic cell differentiation and vessel maturation processes is key to the development of novel, regenerative medicine and tissue engineering approaches. In this review we provide an overview of lymphatic characterisation markers and morphology in development. Furthermore, we describe multiple differentiation processes of the lymphatic system during embryonic, post-natal and pathogenic development. Using the example of pathogenic Kaposi Sarcoma-associated Herpes infection we illustrate the involvement of the Notch and PI3K pathways for lymphatic trans-differentiation. We also discuss the plasticity of certain cell types and bio-factors which enable trans-differentiation towards the lymphatic lineage. Here we argue the importance of pathway-associated induction factors for lymphatic trans-differentiation including growth factors such as VEGF-C and interleukins, and the involvement of extracellular matrix characteristics and dynamics for morphological functionality.