Graham, D. and Brown, Sarah (2010) Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry. Tetrahedron Letters, 51 (38). pp. 5032-5034. ISSN 0040-4039
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2010.07.101
Abstract
Uptake of diagnostic and therapeutic oligonucleotides that specifically target disease can be enhanced by attachment of a cell penetrating peptide. Here we describe the covalent attachment of an oligonucleotide to Tat, a biologically important cell-penetrating peptide, via click chemistry.
| Item type: | Article |
|---|---|
| ID code: | 28552 |
| Keywords: | oligonucleotide peptide conjugates, Tat peptide, click chemistry, Science (General), Chemistry |
| Subjects: | Science > Science (General) Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Mrs Gillian Neeson |
| Date Deposited: | 25 May 2011 16:16 |
| Last modified: | 12 Mar 2012 11:21 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/28552 |
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