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Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry

Graham, D. and Brown, Sarah (2010) Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry. Tetrahedron Letters, 51 (38). pp. 5032-5034. ISSN 0040-4039

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Abstract

Uptake of diagnostic and therapeutic oligonucleotides that specifically target disease can be enhanced by attachment of a cell penetrating peptide. Here we describe the covalent attachment of an oligonucleotide to Tat, a biologically important cell-penetrating peptide, via click chemistry.

Item type: Article
ID code: 28552
Keywords: oligonucleotide peptide conjugates, Tat peptide, click chemistry, Science (General), Chemistry, Biochemistry, Organic Chemistry, Drug Discovery
Subjects: Science > Science (General)
Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Mrs Gillian Neeson
Date Deposited: 25 May 2011 15:16
Last modified: 27 Mar 2014 08:53
URI: http://strathprints.strath.ac.uk/id/eprint/28552

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