Picture of a black hole

Strathclyde Open Access research that creates ripples...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of research papers by University of Strathclyde researchers, including by Strathclyde physicists involved in observing gravitational waves and black hole mergers as part of the Laser Interferometer Gravitational-Wave Observatory (LIGO) - but also other internationally significant research from the Department of Physics. Discover why Strathclyde's physics research is making ripples...

Strathprints also exposes world leading research from the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

Discover more...

Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry

Graham, D. and Brown, Sarah (2010) Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry. Tetrahedron Letters, 51 (38). pp. 5032-5034. ISSN 0040-4039

[img] Microsoft Word (Manuscript_final.doc)
Manuscript_final.doc

Download (316kB)

Abstract

Uptake of diagnostic and therapeutic oligonucleotides that specifically target disease can be enhanced by attachment of a cell penetrating peptide. Here we describe the covalent attachment of an oligonucleotide to Tat, a biologically important cell-penetrating peptide, via click chemistry.