Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

cis-2,6-Dimethylpiperidide: a structural mimic for TMP (2,2,6,6-tetramethypiperidide) or DA (diisopropylamide)?

Campbell, R. and Conway, B. and Garcia-Alvarez, P. and Kennedy, A.R. and Klett, J. and O'Hara, C.T. and Mulvey, R.E. and Robertson, G. and , EPSRC (Funder) (2010) cis-2,6-Dimethylpiperidide: a structural mimic for TMP (2,2,6,6-tetramethypiperidide) or DA (diisopropylamide)? Dalton Transactions, 39. pp. 511-519. ISSN 1472-7773

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Four novel heterobimetallic ate complexes containing cis-2,6-dimethylpiperidide (cis-DMP) have been prepared and characterised. Two contain one cis-DMP ligand, namely the bisalkyl-amido lithium, and sodium zincates [(TMEDA)·MZn(cis-DMP)(tBu)2] (M = Li for 1, Na for 2). Both 1 and 2 are synthesised by co-complexation of the respective alkali metal amide with di-tert-butylzinc in the presence of a molar equivalent of N,N,N′,N′-tetramethylethylenediamine (TMEDA) in a hydrocarbon medium. The third complex, containing two cis-DMP ligands, is the alkyl-bisamido sodium zincate [(TMEDA)·NaZn(cis-DMP)2(tBu)] 3. Complex 3 is prepared from 2via a disproportionation reaction where the by-product is [(TMEDA)·NaZn(tBu)3]. Another alkyl-diamido sodium zincate, [(TMEDA)·NaZn(DIBA)2(tBu)] 4 is synthesised by utilising diisobutylamine [DIBA(H)]. This reaction emphasises the generality of this disproportionation process. Complex 5 contains three cis-DMP ligands and is a tris-amido sodium magnesiate [(TMEDA)·NaMg(cis-DMP)3]. It is prepared by treating an equimolar mixture of butylsodium and dibutylmagnesium with three and one molar equivalents of cis-DMP(H) and TMEDA respectively, in hydrocarbon solution. By comparison of 1-5 with appropriate complexes from the literature, it has been possible to experimentally determine that the steric bulk of cis-DMP closely resembles that of DA but is considerably less bulky than 2,2,6,6-tetramethylpiperidide (TMP).