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Postnatal weight loss in substitute methdadone-exposed infants: implications for the management of breast feeding

Dryden, C. and Young, D. and Campbell, N. and Mactier, H. (2010) Postnatal weight loss in substitute methdadone-exposed infants: implications for the management of breast feeding. Archives of Disease in Childhood Fetal and Neonatal Edition.

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Abstract

It is widely accepted that maternal drug-exposed infants demonstrate excessive early weight loss, but this has not previously been quantified. Among 354 term, substitute methadone-exposed infants, median maximal weight losses were 10.2% and 8.5% for breast- and formula-fed infants, respectively (p=0.003). Weight loss was less in small for gestational age compared to appropriately grown infants (p<0.001). There was no association between maximal weight loss and plasma sodium concentration (p=0.807). Relative to non-drug exposed infants, weight loss was more marked in formula-fed infants, 48% of whom demonstrated weight loss in excess of the 95th centile (compared to 23% of exclusively breastfed infants; p<0.001). Median weight loss nadir was on day 5, excepting those infants exclusively breastfed (day 4). These data suggest that excessive neonatal weight loss among breastfed infants of drug-misusing mothers does not necessarily reflect poorly established lactation and may help to guide management of breast feeding in this population.

Item type: Article
ID code: 28049
Notes: Epub ahead of print
Keywords: Mathematics, Statistics, Medicine(all)
Subjects: Science > Mathematics
Social Sciences > Statistics
Department: Faculty of Science > Mathematics and Statistics
Related URLs:
    Depositing user: Mrs Carolynne Westwood
    Date Deposited: 13 Oct 2010 10:41
    Last modified: 05 Sep 2014 06:55
    URI: http://strathprints.strath.ac.uk/id/eprint/28049

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