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Structure and aggregation of a helix-forming polymer

Magee, James E. and Song, Zhankai and Curtis, Robin A. and Lue, L. (2007) Structure and aggregation of a helix-forming polymer. Journal of Chemical Physics, 126 (14). ISSN 0021-9606

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Abstract

We have studied the competition between helix formation and aggregation for a simple polymer model. We present simulation results for a system of two such polymers, examining the potential of mean force, the balance between intermolecular and intramolecular interactions, and the promotion or disruption of secondary structure brought on by the proximity of the two molecules. In particular, we demonstrate that proximity between two such molecules can stabilize secondary structure. However, for this model, observed secondary structure is not stable enough to prevent collapse of the system into an unstructured globule.