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Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Structural elaboration of the surprising ortho-zincation of benzylmethylether

Mulvey, R.E. and Kennedy, A.R. and Klett, J. and O'Hara, C.T. (2010) Structural elaboration of the surprising ortho-zincation of benzylmethylether. Chemical Communications (London), 46. pp. 2319-2321. ISSN 0009-241X

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Abstract

Breaking with convention, the reaction of the sodium zincate, [(TMEDA)Na(μ-TMP)(μ-tBu)Zn(tBu)] with benzyl methyl ether (PhCH2OMe) produces exclusively an ortho-zincated intermediate [(TMEDA)Na(μ-TMP)(μ-C6H4CH2OMe)Zn(tBu)] instead of the expected 'thermodynamic' α-metallated product.