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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Structural elaboration of the surprising ortho-zincation of benzylmethylether

Mulvey, R.E. and Kennedy, A.R. and Klett, J. and O'Hara, C.T. (2010) Structural elaboration of the surprising ortho-zincation of benzylmethylether. Chemical Communications (London), 46. pp. 2319-2321. ISSN 0009-241X

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Abstract

Breaking with convention, the reaction of the sodium zincate, [(TMEDA)Na(μ-TMP)(μ-tBu)Zn(tBu)] with benzyl methyl ether (PhCH2OMe) produces exclusively an ortho-zincated intermediate [(TMEDA)Na(μ-TMP)(μ-C6H4CH2OMe)Zn(tBu)] instead of the expected 'thermodynamic' α-metallated product.