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Cleave and capture chemistry illustrated through bimetallic-induced fragmentation of tetrahydrofuran

Mulvey, R.E. and Blair, V.L. and Clegg, William and Kennedy, A.R. and Klett, J. and Russo, L. (2010) Cleave and capture chemistry illustrated through bimetallic-induced fragmentation of tetrahydrofuran. Nature Chemistry, 2. pp. 588-591. ISSN 1755-4330

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Abstract

The cleavage of ethers is commonly encountered in organometallic chemistry though rarely studied in the context of newly emerging bimetallic reagents. Recently it was reported that a bimetallic sodium-zinc base can deprotonate cyclic tetrahydrofuran (THF) under mild conditions without opening its heterocyclic (OC4) ring. In marked contrast to this synergic sedation, herein we show that switching to more reactive sodium-magnesium or sodium-manganese bases promotes cleavage of at least six bonds in THF, but the ring fragments are uniquely captured in separate crystalline complexes. Oxide fragments occupy guest positions in bimetallic inverse crown ethers and C4 fragments ultimately appear in bimetallated butadiene molecules. These results demonstrate the special synergic reactivity that can be executed by bimetallic reagents, including the ability to capture and control and thereby study reactive fragments from sensitive substrates.

Item type: Article
ID code: 27621
Keywords: inorganic chemistry, organometallic chemistry , THF, cyclic tetrahydrofuran, Chemistry, Chemical Engineering(all), Chemistry(all)
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Depositing user: Mrs Gillian Neeson
Date Deposited: 12 May 2011 14:32
Last modified: 24 Apr 2015 04:10
URI: http://strathprints.strath.ac.uk/id/eprint/27621

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