Picture of a black hole

Strathclyde Open Access research that creates ripples...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of research papers by University of Strathclyde researchers, including by Strathclyde physicists involved in observing gravitational waves and black hole mergers as part of the Laser Interferometer Gravitational-Wave Observatory (LIGO) - but also other internationally significant research from the Department of Physics. Discover why Strathclyde's physics research is making ripples...

Strathprints also exposes world leading research from the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

Discover more...

Cleave and capture chemistry illustrated through bimetallic-induced fragmentation of tetrahydrofuran

Mulvey, R.E. and Blair, V.L. and Clegg, William and Kennedy, A.R. and Klett, J. and Russo, L. (2010) Cleave and capture chemistry illustrated through bimetallic-induced fragmentation of tetrahydrofuran. Nature Chemistry, 2. pp. 588-591. ISSN 1755-4330

[img] Microsoft Word (Revised_Nature_Chemistry_Manuscript_-_REM.doc)
Revised_Nature_Chemistry_Manuscript_-_REM.doc - Preprint

Download (82kB)

Abstract

The cleavage of ethers is commonly encountered in organometallic chemistry though rarely studied in the context of newly emerging bimetallic reagents. Recently it was reported that a bimetallic sodium-zinc base can deprotonate cyclic tetrahydrofuran (THF) under mild conditions without opening its heterocyclic (OC4) ring. In marked contrast to this synergic sedation, herein we show that switching to more reactive sodium-magnesium or sodium-manganese bases promotes cleavage of at least six bonds in THF, but the ring fragments are uniquely captured in separate crystalline complexes. Oxide fragments occupy guest positions in bimetallic inverse crown ethers and C4 fragments ultimately appear in bimetallated butadiene molecules. These results demonstrate the special synergic reactivity that can be executed by bimetallic reagents, including the ability to capture and control and thereby study reactive fragments from sensitive substrates.